{"id":3275,"date":"2022-05-10T10:00:00","date_gmt":"2022-05-10T15:00:00","guid":{"rendered":"https:\/\/singularityumexicosummit.com\/?p=3275"},"modified":"2022-05-10T10:00:00","modified_gmt":"2022-05-10T15:00:00","slug":"first-ever-artificial-neuron-could-let-us-repair-brain-injuries-with-silicon","status":"publish","type":"post","link":"https:\/\/singularityumexico.com\/en\/first-ever-artificial-neuron-could-let-us-repair-brain-injuries-with-silicon\/","title":{"rendered":"First-Ever Artificial Neuron Could Let Us Repair Brain Injuries with Silicon"},"content":{"rendered":"<p>The merging of man and machine is a staple of sci-fi and at the heart of the philosophy of transhumanism.&nbsp;But interfacing our brains with computers has proven incredibly hard, despite&nbsp;the fact that&nbsp;both essentially run on electrical impulses.<\/p>\n\n\n\n<p>Imagine,&nbsp;for example,&nbsp;if a brain injury could be repaired with a computer chip. That may not be too far off;&nbsp;this week, researchers reported on a&nbsp;\u201csolid-state neuron\u201d&nbsp;that accurately models&nbsp;the behavior of biological&nbsp;nerve cells.&nbsp;In&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13177-3\">a paper in&nbsp;<em>Nature Communications<\/em><\/a><em>,&nbsp;<\/em>the&nbsp;team&nbsp;says&nbsp;the devices could be&nbsp;plugged into biological neural&nbsp;circuits&nbsp;to repair damage or disease.<\/p>\n\n\n\n<p>\u201cUntil now neurons have been like black boxes, but we have managed to open the black box and peer inside,\u201d project leader Alain Nogaret, from the University of Bath in the UK, said in&nbsp;<a href=\"https:\/\/www.bath.ac.uk\/announcements\/world-first-as-artificial-neurons-developed-to-cure-chronic-diseases\/\">a press release<\/a>. \u201cOur work is paradigm-changing because it provides a robust method to reproduce the electrical properties of real neurons in minute detail.\u201d<\/p>\n\n\n\n<p>A major reason it\u2019s been so hard to accurately replicate the behavior of neurons in silicon is because the way they respond to stimuli is non-linear. In other words, a signal twice as strong won\u2019t necessarily elicit a response that\u2019s twice as strong.<\/p>\n\n\n\n<p>The researchers solved the problem by collecting data from two types of rat neuron.&nbsp;The first&nbsp;was&nbsp;from the hippocampus region of the brain, which is involved in learning and memory, and the second from the respiratory center, which controls breathing.<\/p>\n\n\n\n<p>They used this data to estimate the parameters that control how ions flow through the neurons and then used those parameters&nbsp;to create a model that explains how neurons respond to stimuli from other nerves. They then used that&nbsp;model to build analogue silicon chips that accurately modeled the behavior of real neurons.<\/p>\n\n\n\n<p>To test their chips, they subjected them&nbsp;to 60 different stimulation protocols&nbsp;and compared their responses&nbsp;to those&nbsp;seen in rat hippocampal&nbsp;and&nbsp;brain stem neurons. The chips achieved a 94&nbsp;percent&nbsp;accuracy.<\/p>\n\n\n\n<p>Critically, the bionic neurons use just&nbsp;140 nanoWatts of power\u2014a billionth&nbsp;the amount&nbsp;of a regular microprocessor, which makes them much more practical for long-term applications inside the body. Each chip is&nbsp;<a href=\"https:\/\/www.ft.com\/content\/05277790-15b1-11ea-9ee4-11f260415385\">roughly 0.1&nbsp;millimeters&nbsp;in diameter<\/a>, but many of them would need to be combined to create a practical implant, which would be a few millimeters wide.<\/p>\n\n\n\n<p>The researchers have already spun out a company called Ceryx to start developing a smart pacemaker that uses the bionic neurons to respond to signals rather than simply providing a steady beat like a regular pacemaker. But they say their approach is generic and could be used to replicate any of the body\u2019s many different types of neurons.<\/p>\n\n\n\n<p>That could make it possible to repair defective circuits&nbsp;that&nbsp;cause&nbsp;conditions like heart failure and sleep apnea, but could also potentially replace damaged nerves caused by spinal injuries or help connect robotic limbs to people\u2019s nervous systems, the researchers&nbsp;<a href=\"https:\/\/www.theguardian.com\/science\/2019\/dec\/03\/bionic-neurons-could-enable-implants-to-restore-failing-brain-circuits\">told&nbsp;<em>The Guardian<\/em><\/a><em>.&nbsp;<\/em><\/p>\n\n\n\n<p>One potential limitation is that the bionic neurons&nbsp;<a href=\"https:\/\/www.cnet.com\/news\/scientists-develop-artificial-nerve-cells-which-behave-just-like-real-cells\/\">do not replicate the complex connectivity<\/a>&nbsp;of real ones. Their model doesn\u2019t cover the many branching dendrites that connect neurons to&nbsp;each other,&nbsp;and adding those dynamics might require further components.<\/p>\n\n\n\n<p>The researchers also say they are&nbsp;a&nbsp;long way from replicating larger, more complex brain circuits, and light years off&nbsp;from&nbsp;being able to reproduce an entire brain.&nbsp;<\/p>\n\n\n\n<p>University of Manchester\u2019s Stephen Furber, who has designed a&nbsp;<a href=\"https:\/\/singularityhub.com\/2018\/11\/19\/the-million-core-spinnaker-supercomputer-is-up-and-running\/\">million-processor&nbsp;computer called SpiNNaker<\/a>&nbsp;designed to model large-scale brain networks, told&nbsp;<em>The Guardian<\/em>&nbsp;that using this approach to create networks of even a few hundred million neurons would be unfeasible\u2014and the brain contains roughly 86 billion&nbsp;of them.<\/p>\n\n\n\n<p>\u201cBecause the approach is detailed and laboriously painstaking, it can really only be applied in practice to smallish neural units, such as the respiratory neurons described above, but there are quite a few critical small neural control circuits that are vital to keeping us alive,\u201d he added.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-background has-black-background-color has-black-color is-style-wide\"\/>\n\n\n\n<p><em>Image Credit: An artificial neuron in its protective casing. Photo courtesy of\u00a0<a href=\"https:\/\/www.bath.ac.uk\/announcements\/world-first-as-artificial-neurons-developed-to-cure-chronic-diseases\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Bath<\/a><\/em><\/p>\n\n\n\n<p><strong>Author:<\/strong><br>I am a freelance science and technology writer based in Bangalore, India. My main areas of interest are engineering, computing and biology, with a particular focus on the intersections between the three.<a href=\"https:\/\/singularityhub.com\/author\/egent\/\" target=\"_blank\" rel=\"noreferrer noopener\">Learn More<\/a><\/p>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"https:\/\/singularityhub.com\/2019\/12\/06\/first-ever-artificial-neuron-could-let-us-repair-brain-injuries-with-silicon\/\" target=\"_blank\" rel=\"noreferrer noopener\">Original Article<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The merging of man and machine is a staple of sci-fi and at the heart of the philosophy of transhumanism.&nbsp;But interfacing our brains with computers has proven incredibly hard, despite&nbsp;the fact that&nbsp;both essentially run on electrical impulses. Imagine,&nbsp;for example,&nbsp;if a brain injury could be repaired with a computer chip. That may not be too far [&#8230;]\n","protected":false},"author":1,"featured_media":3276,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"episode_type":"audio","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","footnotes":""},"categories":[13],"tags":[28,29,77,78,57,58,55,56,79,80],"series":[],"class_list":["post-3275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articulos-ingles","tag-biotechnology","tag-biotecnologia","tag-future-of-health","tag-futuro-de-la-salud","tag-nanotechnology","tag-nanotecnologia","tag-neurociencia","tag-neuroscience","tag-transhumanism","tag-transhumanismo"],"episode_featured_image":"https:\/\/singularityumexico.com\/wp-content\/uploads\/2022\/05\/artificial-neuron.jpg","episode_player_image":"https:\/\/singularityumexico.com\/wp-content\/uploads\/2023\/05\/11711533-1673157178559-89a95be153719-4-scaled.jpg","download_link":"","player_link":"","audio_player":false,"episode_data":{"playerMode":"dark","subscribeUrls":{"apple_podcasts":{"key":"apple_podcasts","url":"","label":"Apple Podcasts","class":"apple_podcasts","icon":"apple-podcasts.png"},"stitcher":{"key":"stitcher","url":"","label":"Stitcher","class":"stitcher","icon":"stitcher.png"},"google_podcasts":{"key":"google_podcasts","url":"","label":"Google Podcasts","class":"google_podcasts","icon":"google-podcasts.png"},"spotify":{"key":"spotify","url":"","label":"Spotify","class":"spotify","icon":"spotify.png"}},"rssFeedUrl":"https:\/\/singularityumexico.com\/en\/feed\/podcast\/the-feedback-loop-by-singularity","embedCode":"<blockquote class=\"wp-embedded-content\" data-secret=\"NfES47By8i\"><a href=\"https:\/\/singularityumexico.com\/en\/first-ever-artificial-neuron-could-let-us-repair-brain-injuries-with-silicon\/\">First-Ever Artificial Neuron Could Let Us Repair Brain Injuries with Silicon<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/singularityumexico.com\/en\/first-ever-artificial-neuron-could-let-us-repair-brain-injuries-with-silicon\/embed\/#?secret=NfES47By8i\" width=\"500\" height=\"350\" title=\"&#8220;First-Ever Artificial Neuron Could Let Us Repair Brain Injuries with Silicon&#8221; &#8212; Singularity Mexico\" data-secret=\"NfES47By8i\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! 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